FIGURE 4.
Sialic acids modulate Kv2.1 activation but do not affect slow inactivation. G-V (A) and steady-state inactivation (B) relationships for Kv2.1 under conditions of full and reduced sialylation. Data are the means ± S.E. and are fit to single Boltzmann relationships (lines). Inset (A), typical whole cell Kv2.1 current traces. Black lines/circles, +sialic acids (Pro5, n = 14); gray lines/symbols, −sialic acids (Lec2 (circles), n = 12; sialidase-treated Pro5 (triangles) or Lec2 (inverted triangles), n = 3–4).