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Model for the cleavage of ANP by IDE. A, biased stochastic mode for the cleavage of ANP by IDE. ANP cleavage by IDE has revealed a novel mechanism for substrate hydrolysis by IDE, involving a biased stochastic mode, as opposed to the previously proposed sequential mode. B, four modes of substrate cleavage by IDE exemplified by the cleavages of insulin, Aβ, bradykinin, and ANP. See “Results” for details about these four modes.
