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Efficacy of furin and/or PC5/6 KO in hepatocytes. Furin and PC5/6 transcript levels were determined by QPCR in WT (open bars) and hKO (gray bars) livers from littermates and were normalized to WT levels. Means ± S.E. and p values (bilateral Student's t test) are given and n = 5 to 14 mice per group. **, p ≤ 0.005 and ***, p ≤ 0.0005.
