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. 2010 Dec 2;286(6):4280–4291. doi: 10.1074/jbc.M110.200774

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© 2011 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 6. — G6 improves the M:E ratio in a mouse model of Jak2-V617F-mediated hyperplasia by reducing HEL cell engraftment in the bone marrow. After a 3-week period of drug or vehicle administration, all groups were euthanized and histological sections of the femurs were prepared. A, representative H&E stained bone marrow sections for each treatment group. B, number of mature myeloid and erythroid cells was determined. #, p < 0.05 relative to naïve; *, p < 0.05 relative to HEL+DMSO. C, myeloid and erythroid cell numbers plotted as the M:E ratio. #, p < 0.05 relative to naïve; *, p < 0.05 relative to HEL+DMSO. D, representative flow cytometry profiles of human CD45+ cells from each treatment group are shown. E, average percentages of human CD45+ cells present in the bone marrow were plotted as a function of treatment group.