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. 2010 Dec 10;286(6):4454–4460. doi: 10.1074/jbc.M110.185819

FIGURE 5.

FIGURE 5.

Effect of hQC overexpression and QC knock-out on behavioral performance in 5XFAD mice. A and B, 5XFAD/hQC mice showed a significantly reduced motor performance in balance beam (A) and string suspension task (B) compared with 5XFAD mice. C, in addition, working memory deficits were detected in 5XFAD/hQC compared with 5XFAD mice using Y- and cross-maze (E). Interestingly, the 5XFAD/QC-KO mice showed a rescue of working memory deficits with alternation frequencies indistinguishable from wild-type mice. D and F, the number of arm entries in Y- and cross-maze did not differ among the groups. *, p < 0.05; **, p < 0.01; ***, p < 0.001.