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Phosphate-binding pocket of TopBP1 BRCT7/8. A, stick representation of the TopBP1 BRCT7/8 (yellow) in complex with the BACH1 phospho-peptide (orange). Hydrogen bonding and electrostatic interactions are indicated by dotted lines. B, phosphate-binding pocket of apo TopBP1 BRCT7/8. C, FP binding results for TopBP1 BRCT7/8 phosphate-binding pocket mutants. GST fusion BRCT7/8 variants were purified and used in the assay. Triplicate data points are represented as the means ± S.E.
