FIGURE 5.

Enhanced recognition of the S1/N1 CoRNR box motif by the x-RARα fusion proteins. A, binding of individual CoRNR box motifs to RARα, PML-RARα, or PLZF-RARα. EMSA supershifts were performed as in Fig. 4A but using corepressor subdomains limited to the individual S1, S2, S3, N1, N2, or N3 CoRNR motifs (as indicated above the panels). Both receptor homodimers (left panels) and receptor heteromers (right panels) were tested. B, quantification. The experiment in A was repeated (n = 3) and quantified; the means and S.E. are presented.