. Author manuscript; available in PMC: 2011 Feb 15.

Published in final edited form as: Mol Biochem Parasitol. 2008 Dec 25;164(2):111–117. doi: 10.1016/j.molbiopara.2008.12.007

Table 2.

Cross-resistance profile of wild-type (WT) and paromomycin-resistant (PRr) L. donovani promastigotes

Drug	Mean IC₅₀ ± S.D. (µM)

	Wild-type	PRr
Paromomycin	50.0 ± 2.5	145 ± 3^**
Pentamidine	1.2 ± 0.3	1.8 ± 0.4^*
Amphotericin B	0.05 ± 0.01	0.07 ± 0.01^*
Sb V	35 ± 4.2	23 ± 1.4^*
Miltefosine	15.6 ± 0.25	10.4 ± 0.4^*

IC_50s were determined in promastigotes of paromomycin-sensitive and Paromomycin-resistant strains after 72 h of drug addition. IC₅₀ are given as means ± S.D. of at least two independent determinations with triplicates in each set.

Not significantly different from the corresponding wild-type values.

^**

Statistically different at P<0.0001 when compared to the corresponding values obtained for wild type (WT).