Table 4.

FtsZ inhibitors for bacteria other than Mycobacterium tuberculosis (1).

Compound	Target organism	Mode of action	MIC/IC50 (cell growth inhibition)	Ref.
Viriditoxin	Escherichia coli, Staphylococcus aureus, MRSA, VRE, Enterococcus faecilus	Inhibits GTPase and FtsZ polymerization	4–8 μg/ml (S. aureus and MRSA) 2–16 μg/ml (enterococcus faecalis and VRE)	[68]
Zantrins	Mycobacterium tuberculosis, E. coli, MRSA, VRE	Inhibits GTPase, Z1, Z2, Z4 destabilizes FtsZ polymer, Z5 stabilizes FtsZ assembly		[3]
GTP analogs:				[69,70,71]
▪ BrGTP	E. coli	Inhibits GTPase and FtsZ polymerization assay in reversible competitive mode
▪ GAL analogs	E. coli, S. aureus	Inhibits GTPase activity (E. coli FtsZ), Competitive inhibition of FtsZ polymerization and GTPase assay	0.4–20 mg/ml (S. aureus)
Sanguinarine	Bacillus subtilis, E. coli	Inhibits FtsZ assembly and protofilament bundling, thinner and shorter FtsZ protofilaments (E. coli)		[73]
N-benzyl-3- sulfonamidopyrrolidine	E. coli	Lethal cell filamentation, moderate inhibition of GTPase activity, no effect on FtsZ polymerization	Compound 14–10 μM Compound 15–20 μM	[74]
(±)-dichamanetin	S. aureus, B. subtilis, Mycobacterium smegmatis, E. coli	Inhibits GTPase activity of E. coli FtsZ	1.7–3.4 μM (S. aureus, B. subtilis, M. smegmatis and E. coli)	[78]
(±)-2′-hydroxy-5′-benzylisouvarinol-B	S. aureus, B. subtilis, M. smegmatis, E. coli	Inhibits GTPase activity of E. coli FtsZ	2.3–10.7 μM (S. aureus, B. subtilis, M. smegmatis and E. coli)	[78]

MIC: Minimum inhibitory concentration; VRE: Vancomycin-resistant enterococcus.