Table 3.
Population-specific test on the long-term evolutionary status for the SNPs from the 890 associations from the Global Set.
| Europeans (CEU)a | East Asians (CHB)a | East Asians (JPT)a | Africans (YRI)a | |||||
|---|---|---|---|---|---|---|---|---|
| Replicability | ANCb (%) | DERb (%) | ANCb (%) | DERb (%) | ANCb (%) | DERb (%) | ANCb (%) | DERb (%) |
| ≤66.67% | 19017 | 4533 | 18529 | 4991 | 18623 | 4919 | 19816 | 3757 |
| (n = 441) | (80.8) | (19.2) | (78.8) | (21.2) | (79.1) | (20.9) | (84.1) | (15.9) |
| ≥66.67% | 19783 | 5173 | 19271 | 5620 | 19334 | 5556 | 20789 | 4187 |
| (n = 441) | (79.3) | (20.7) | (77.4) | (22.6) | (77.7) | (22.3) | (83.2) | (16.8) |
| p-value | 4.89 × 10-5 | p-value | 3.19 × 10-4 | p-value | 1.43 × 10-4 | p-value | 0.0144 | |
a CEU = North Americans (Utah) of Northern European ancestry; CHB = Chinese from Beijing; JPT = Japanese from Tokyo; YRI = Yorubans from Ibadan (Nigeria)
b ANC = SNPs with an ancestral major allele (freq ≥ 0.5); DER = SNPs with a derived major allele (freq ≥ 0.5)