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. 2011 Feb 15;6(2):e16916. doi: 10.1371/journal.pone.0016916

Figure 2. Downregulation of ZIC1 expression and frequent hypermethylation of ZIC1 promoter in primary colorectal tumor tissues.

Figure 2

(A) ZIC1 mRNA expression was determined by quantitative real-time PCR in twenty four pairs of primary colorectal tumor and according adjacent non-tumor tissues. The data was analyzed by Wilcoxon matched pairs test. (B) The methylation status of ZIC1 promoter in primary colorectal carcinoma and adjacent non-tumor tissues was determined by MSP. Representative image are shown. T: tumor tissues; N: adjacent non-tumor tissues; M: methylated; U: unmethylated.