Table 2. Representative gene expression profile in ZIC1 transfectants compared with empty vector control (fold change) by cDNA microarray in HCT116 cells.

Gene Symbol	Gene Description	GenbankAccession	FoldChange (*)	Gene Function
			Down-Regulation	cell proliferation, apoptosis, migration, adhesion, and angiogenesis
ANGPT2	angiopoietin 2	NM_001147	0.43	angiogenesis
AOC3	amine oxidase, copper containing 3	NM_003734	0.48	cell adhesion
AVIL	advillin	NM_006576	0.47	cell migration
COL20A1	collagen, type XX, alpha 1	NM_020882	0.37	cell adhesion
CTGF	connective tissue growth factor	NM_001901	0.43	cell proliferation/angiogenesis
CYR61	cysteine-rich, angiogenic inducer, 61	NM_001554	0.42	cell proliferation/cell adhesion
DLEC1	deleted in lung and esophageal cancer 1	NM_007335	0.45	cell proliferation
EFNB3	ephrin-B3	NM_001406	0.47	cell differentiation
GADD45B	growth arrest and DNA-damage-inducible, beta	NM_015675	0.5	cell proliferation/cell apoptosis
KRT14	keratin 14	NM_000526	0.48	epithelial cell differentiation
LAMB2	laminin, beta 2 (laminin S)	NM_002292	0.5	cell adhesion/cell migration
LAMB3	laminin, beta 3	NM_001017402	0.39	cell adhesion/cell migration
MALAT1	metastasis associated lung adenocarcinoma transcript	NR_002819	0.2	cell proliferation/metastasis
MLXIPL	MLX interacting protein-like	NM_032951	0.5	cell proliferation
OSM	oncostatin M	NM_020530	0.49	cell proliferation
PNMA2	paraneoplastic antigen MA2	NM_007257	0.33	cell proliferation
PTPRH	protein tyrosine phosphatase, receptor type, H	NM_002842	0.44	cell apoptosis
RPA4	replication protein A4, 34 kDa	NM_013347	0.37	cell proliferation
SNIP	Smad nuclear interacting protein 1	NM_025248	0.46	cell migration
TACSTD2	tumor-associated calcium signal transducer 2	NM_002353	0.49	cell proliferation

*Fold Change: ZIC1 versus control vector.