Table 1. Common transcription factor binding sites in the 9-gene signature.
Best hit | Weight | Matrix consensus | Transfac ID | Factor name |
GCACCTG | 6.5 | ASCACCTGTTNNCA | M00044 | Snail* |
CAGGTGC | 6.5 | RACAGGTGYA | M00060 | Snail* |
GCACCTG | 6.5 | VNRCACCTGKNC | M00414 | AREB6/ZEB1* |
CAGGTGC | 6.21 | CNNCAGGTGB | M00277 | LMO2 complex* |
CAGGTGC | 6 | RRCAGGTGNCV | M00693 | E12/ELSPBP1* |
CAGGTGC | 6 | CNGNRNCAGGTGNNGNA | M00929 | MyoD* |
GCACCTG | 5.5 | YNYACCTGWVT | M00412 | AREB6/ZEB1* |
GCACCTG | 4 | RRTGNMCYTNNTGAMCCNYNT | M00966 | VDR, CAR, PXR |
GCACCTG | 3.5 | GCTGGNTNGNNCYNG | M00947 | CP2/LBP-1c/LSF |
GCACCTG | 3.5 | RGNACNNKNTGTTCT | M00957 | PR/Progesterone receptor |
GCACCTG | 3.5 | TGGCASNNNGCCAA | M01196 | CTF1 |
A list of binding sites matching to best 7-mer found in promoters of the common EMT gene signature. Three muscle initiator sequences with no further information were excluded.
*E-box binding transcription factors. E12 is part of the LMO2 complex.