Figure 9. IL-22 is not required for clearance of bacteria from the spleen and liver during a secondary systemic LM infection.
B6 and IL-22 KO mice were i.v. infected with ∼1×103 LM, then re-infected six-weeks later with ∼1×106 LM. Spleens and livers were harvested 2 days p.i. and bacterial burdens were determined. A two-way ANOVA did not detect a significant effect of mouse strain (p>0.05). These data are combined from two independent experiments. All data are expressed as the mean + SEM (n = 9/group).