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. 2011 Feb 15;5(2):e962. doi: 10.1371/journal.pntd.0000962

Table 5. Therapeutic category of anti-leishmanial compounds identified in the ex vivo splenic explant system.

Anti-protozoa Anti-bacterial Anti-helmintic
Elipticine Nonactin Pararosaniline Pamoate
Nigericin Aklavine Hydrochloride Naphthofuran d
Cepharanthine Nigericin Cetrimonium Bromide
Disulfiram Naphthofuran d Disulfiram
Tilorone Streptovitacin A
3-phenanthren a 5-methyl-8-quinolinol c Anti-fungal
Benzalkonium Chloride Securinine Pararosaniline Pamoate
Physalin Cepharanthine Naphthofuran d
Chlorhexidine Parthenicin Cetrimonium Bromide
Cloxyquin Disulfiram Disulfiram
Tetrandrine Salinomycin, Sodium Acrisorcin
Clioquinol Rubescensin A Benzalkonium Chloride
Hexachlorophene 7-hydroxychlorpromazine Clioquinol
Lasalocid Sodium Lasalocid Sodium Hexachlorophene
Lasalocid Sodium
Anti-neoplastic Topical/Antiseptics Antimycin A
Aklavine Hydrochloride 5-methyl-8-quinolinol c 5-methyl-8-quinolinol c
Thaspine, Acetate Cetrimonium bromide
Ellipticine Benzalkonium chloride Immune response regulator
NSC 134754 Chlorhexidine n6-Isopentenyladenine
Streptovitacin A Clioquinol Spermidine Trihydrochloride
Cepharanthine Hexachlorophene NSC 13480
Benzethonium Chloride Cetylpyridinium Chloride 6,4′-Dimethoxyflavone
Rubescensin A NSC 371488
10-Methyl-9-anthracenyl f Anti-viral Sumilit bbm
Tilorone Nigericin Securinine
Crassin Cepharanthine Cepharanthine
Tetrandrine Trimethoxychalcone g
NSC 305819 Tilorone Anti-obesity/Anti-psychotics
NSC 371488 Benzalkonium Chloride 1h-benz[de]isoquinoline b
Clioquinol Crassin Acetate Nortriptyline Hydrochloride
Fastigilin B Disulfiram
Thioxanthen-9 e Undefined h Orlistat
Crassin acetate Thiomethylpromazine
6,4′-dimethoxyflavone Chlorpromazine
7-hydroxychlorpromazine
Maprotiline hydrochloride
a

3-phenanthrenemethanol, alpha.-[(diethylamino)methyl]-,hydrochloride.

b

1h-benz[de]isoquinoline-1,3(2 h)- dione, 5-amino-2-[2-(diethylamino)ethyl]-

c

7-(2-(6-ethoxy-1-methyl-1lambda(5)-quinolin-2-yl)vinyl)-5-methyl-8-quinolinol.

d

naphtho(2,1-b)furan, 4 methoxy-2 -nitro-

e

thioxanthen-9-one, 4-(hydroxymethyl)-1-[(2-piperidinoethyl)amino.

f

10-Methyl-9-anthracenyl) methyl carbamimidothioic acid ester hydrochloride.

g

2′,4-dihydroxy-3,4′,6′ Trimethoxychalcone.

h

Undefined activity: pyrimido[4,5-b]quinoline-2,4(3 h,10 h)-dione, 5-[[3-(dimethylamino)propyl]amino]- 3,10-dimethyl-,monohydrochloride]-; 17-(1-((2-(dimethylamino)ethyl)amino)ethyl) estra-1,3,5(10)-trien-3-ol; N1-(7-chloro-1,2,3,4-tetrahydro-9-acridinyl)-N3,N3-dimethyl-1,3-propanediamine; 2-[(2E)-2-hydroxyimino-4,6,6-trimethyl-1-cyclohex-3-enyl]-4,6,6-trimethyl-cyclohex-3-en-1-ol; 3-(12H-benzo[a]phenothiazin-12-yl)-N,N-dimethyl-1-propanamine; 5-Phenyl-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-5-ol; 7-chloro-N-(4-(1-piperidinyl)cyclohexyl)-4-quinolinamine; 2-(3-dimethylaminopropylamino)-1,4-dihydroxy-anthracene-9,10-dione; 17-(Bis(2-hydroxyethyl)amino)androst- 5-en-3-ol; N1-7-chloro-4-quinolinyl)-N2-cyclohexyl-1,2-ethanediamine; 6-methoxy-N-[2-(2-piperidyl)ethyl]quinolin-8-amine.