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. Author manuscript; available in PMC: 2012 Mar 1.
Published in final edited form as: Arch Biochem Biophys. 2010 Oct 29;507(1):95–110. doi: 10.1016/j.abb.2010.10.016

Fig. 32.

Fig. 32

Proposed pathway for the cytochrome P450-catalyzed oxidation of an indazole drug candidate to a mutagenic oxaziridine that subsequently ring opens and eliminates the piperidine moiety. The second product, indazalone, is hydrolyzed to yield benzoic acid and nitrogen gas. (See reference 84 for the structure of the R group.)