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. Author manuscript; available in PMC: 2011 Nov 4.
Published in final edited form as: Eur J Immunol. 2010 Jul;40(7):1985–1994. doi: 10.1002/eji.200940282

Figure 2. CD28−/−BTLA−/− mice respond to allergen challenge in vivo.

Figure 2

Mice of each genotype were systemically sensitized with OVA/Alum then given an inhaled challenge of OVA as described in the Materials and methods. Samples were collected for analysis 3 days following the inhaled challenge. A) Total BAL cell number and B) differential analysis of cells recovered from the BAL fluid. C) Histologic examination of H&E-stained sections confirms peribronchial and perivacular inflammation in the lungs of the C57BL/6, BTLA−/− and CD28−/−BTLA−/− mice, but not the CD28−/− mice. Data show mean + SD (n=5 mice per group) and are representative of more than 5 independent experiments, *p<0.01 compared to CD28−/− mice.