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. Author manuscript; available in PMC: 2011 Nov 4.
Published in final edited form as: Eur J Immunol. 2010 Jul;40(7):1985–1994. doi: 10.1002/eji.200940282

Figure 6. CTLA4-Ig does not inhibit inflammation in NOS2−/− mice.

Figure 6

C57BL/6 or NOS2−/− mice were sensitized and challenged with OVA. CTLA4-Ig was administered at the time of challenge and specimens collected 3 days later. CTLA4-Ig effectively suppressed allergic airway inflammation in the C57BL/6 mice but not the NOS2−/− mice as shown by A) BAL cell number, B) differential analysis and C) histology of H & E stained lung sections. Data are representative of 2 independent experiments. N= 5 mice per group in each experiment.