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. 2010 Nov 16;6(8):1196–1197. doi: 10.4161/auto.6.8.13478

Figure 1.

Figure 1

A model for the role of DsbA-L in obesity/ER stress-induced adiponectin downregulation. Obesity induces ER stress in adipocytes, leading to increased adiponectin misfolding and subsequent degradation by the autophagy-dependent pathway. DsbA-L suppresses ER stress and facilitates adiponectin assembly and secretion.