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. 2010 Nov 23;104(1):138–145. doi: 10.1038/sj.bjc.6606017

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Copyright © 2011 Cancer Research UK

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TACE in situ hybridisation signals in head and neck tissues and TIMP3 in situ hybridisation signals in stromal cells surrounding HNSCC, dysplastic and normal epithelium. In situ hybridisation signals of paraffin sections were scored semiquantitatively. TACE mRNA expression levels were compared between tumour and normal epithelium or tumour and dysplastic epithelium (A). Dysplastic areas were compared with normal epithelium (B). TIMP3 mRNA expression in stromal areas surrounding tumour epithelium were compared with normal or dysplastic epithelium (C). Stromal areas surrounding dysplastic areas were compared with normal epithelium (D). Statistical significance was calculated using nonparametric sign test. The P-values of <0.05 were defined as statistically significant (^*P<0.05; ^**P<0.01; ^***P<0.001).