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. 2010 Nov 23;104(1):138–145. doi: 10.1038/sj.bjc.6606017

Table 1. Expression of TACE mRNA in HNSCC and TIMP3 mRNA in stromal tissues in relation to clinicopathological parameters.

Clinicopathological feature n TACElo TACEhi P-value n TIMP3STRlo TIMP3STRhi P-value
Quantification ISH ISH
Age
 ⩽60 years 50 38 12 >0.5 50 35 15 0.312
 >60 years 55 44 11   56 44 12  
                 
Sex
 Male 69 53 16 >0.5 71 51 20 0.364
 Female 36 29 7   35 28 7  
                 
Nodal status
 LN− 61 53 8 0.009 61 47 14 >0.5
 LN+ 30 19 11   31 22 9  
                 
Tumour stage
 T1 39 61 12 0.019 39 60 13 0.031
 T2 34       34      
 T3 8 18 11   8 18 11  
 T4 21       21      
                 
Histological grading
 G1 13 64 17 >0.5 13 62 19 >0.5
 G2 68       68      
 G3 24 18 6   24 17 7  
                 
TIMP3 (ISH)
 TIMP3STRlo 77 64 13 0.022        
 TIMP3STRhi 26 16 10          

Abbreviations: HNSCC=squamous cell carcinoma of the head and neck; TACE=tumour necrosis factor (TNF)-α converting enzyme; LN=lymph node; TIMP3=tissue inhibitor of metalloproteinases 3; ISH=in situ hybridisation. Bold and italic entries indicate statistically significant values.