Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2010 Nov 16;104(1):155–165. doi: 10.1038/sj.bjc.6605994

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2011 Cancer Research UK

This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

TSPAN8 is expressed by invasive melanoma cells in culture and in melanoma lesions. (A) Non-invasive (M4Be, M3Ge, M3Da, M1Do cell lines and IC8, T1C11 clones) and invasive melanoma cells (WM793, SKMel28 cell lines and T1C3, TW12, T1P26 clones) were cell surface stained with antibodies directed against TSPAN8 and CAPG. Filled histograms represent specific and open histograms isotype-matched control antibodies. Results are representative of three independent experiments. (B) Representative immunohistochemical expression of TSPAN8 immunostaining in normal skin, benign nevus, RGP and VGP melanomas, and lymph node metastases. Note negative staining of cells from normal skin, except for eccrine glands, which was useful as an internal positive control. The square represents the area of magnification shown in the inset. Open arrows pointing at positive stained junctional nests of melanocytes. Black arrow pointing at a dermal nest of stained cells.