Figure 1.

Schematic diagram of the human bcl-2 proto-oncogene showing the 18 bp purine–pyrimidine-rich motif at the 3′UTR, the triplex target sequence relative to the translation start site (+1946 to +1963) and the TFOs and control oligonucleotides used in this study. Except for TFO3 and 4, all ODNs are phosphorothioated at their 5′- and 3′-ends and amino-linked at their 3′-ends. TFO3 is a pure phosphodiester ODN without any modifications and TFO4 is only amino-linked at its 3′-end.