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. 2010 Nov 30;104(1):101–109. doi: 10.1038/sj.bjc.6606019

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Copyright © 2011 Cancer Research UK

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α-Tocopherol ether-linked acetic acid (α-TEA) suppresses AKT, ERK, mTOR, as well as their downstream targets. HCC-1954 and MCF-7 cells were treated with 20 and 40 μM α-TEA, respectively, for 9, 15, and 24 h. (A) Protein levels of pAKT (Ser-473 and Ser-308), pGSK (α/β) (Ser 21/9), pBad (Ser-136), pcaspase-9 (Ser-196), as well as levels of total AKT, GSK, Bad, and caspase-9 were determined by western blot analyses. (B) Protein levels of pERK1/2, pp90RSK (Ser-380), and pBad (Ser-112), as well as total ERK, p90RSK, and Bad were determined by western blot analyses. (C) Protein levels of pmTOR (Ser-2448), pp70S6K (Thr-389), and p4E-BP1 (Thr-37/46), and levels of total mTOR, p70S6K, and 4E-BP1 were determined by western blot analyses. Data are representative of two separate experiments.