Table 3. Duration and intensity of antidepressant medication use among colorectal cancer cases and matched controls in Northern Denmark, 1991–2008 (number, %).

	Cases		Controls
	N=9979	%	N=99 970	%	OR a	95% CI
Tricyclic antidepressants
Short-term use
Never/rare use	9614	96	95 800	96	1.00
Low intensity	78	0.8	925	0.9	0.86	0.68, 1.09
Medium intensity	76	0.8	969	1.0	0.80	0.63, 1.01
High intensity	74	0.7	750	0.8	1.01	0.80, 1.29
Long-term use
Low intensity	51	0.5	524	0.5	1.00	0.75, 1.34
Medium intensity	33	0.3	349	0.4	0.98	0.69, 1.41
High intensity	53	0.5	473	0.5	1.17	0.88, 1.56
Selective serotonin reuptake inhibitors
Short-term use
Never/rare use	9128	91	90 900	91	1.00
Low intensity	191	1.9	1865	1.9	1.04	0.89, 1.21
Medium intensity	216	2.2	2229	2.2	0.98	0.85, 1.13
High intensity	230	2.3	2599	2.6	0.90	0.78, 1.03
Long-term use
Low intensity	99	1.0	1075	1.1	0.94	0.76, 1.16
Medium intensity	62	0.6	648	0.7	0.97	0.74, 1.26
High intensity	53	0.5	474	0.5	1.13	0.85, 1.51
Other antidepressants
Short-term use
Never/rare use	9689	97	96 654	97	1.00
Low intensity	109	1.1	1268	1.3	0.87	0.72, 1.07
High intensity	126	1.3	1212	1.2	1.07	0.88, 1.29
Long-term use
Low intensity	39	0.4	407	0.4	0.99	0.71, 1.38
High intensity	16	0.2	249	0.3	0.67	0.40, 1.11

Abbreviations: CI=confidence interval; NSAIDs=non-steroidal anti-inflammatory drugs; OR=odds ratio.

^aAdjusted for diabetes, alcoholism, inflammatory bowel disease, use of NSAIDs, use of statins, use of hormone replacement therapy, use of low-dose aspirin and high-dose aspirin, use of neuroleptics, and marital status.