Table 3. Binary analysis.
|
Univariate
|
Multivariate
*
|
||||||||
|---|---|---|---|---|---|---|---|---|---|
| Cancer type | Exposed | Case | Control | OR | 95% | CI | OR | 95% | CI |
| Glioma | No | 706 | 1317 | 1 | 1 | ||||
| Yes | 67 | 185 | 0.66 | 0.49 | 0.89 | 0.59 | 0.42 | 0.81 | |
| Colorectal | No | 5574 | 10 543 | 1 | 1 | ||||
| Yes | 658 | 1467 | 0.85 | 0.77 | 0.94 | 0.84 | 0.75 | 0.94 | |
| Brain | No | 505 | 1013 | 1 | 1 | ||||
| (excl glioma) | Yes | 94 | 151 | 1.26 | 0.95 | 1.67 | 1.00 | 0.72 | 1.38 |
| Breast | No | 8651 | 16 834 | 1 | 1 | ||||
| Yes | 1642 | 3262 | 0.98 | 0.92 | 1.05 | 0.97 | 0.91 | 1.04 | |
| Lung | No | 5555 | 10 992 | 1 | 1 | ||||
| Yes | 982 | 1522 | 1.30 | 1.19 | 1.42 | 1.14 | 1.02 | 1.28 | |
| Prostate | No | 6861 | 13 112 | 1 | 1 | ||||
| Yes | 670 | 1217 | 1.06 | 0.96 | 1.17 | 0.94 | 0.84 | 1.04 | |
| All | No | 27 841 | 53 790 | 1 | 1 | ||||
| Yes | 4112 | 7801 | 1.03 | 0.99 | 1.07 | 0.93 | 0.89 | 0.97 | |
Abbreviations: OR=odds ratio; CI=confidence interval. Patients with repeat prescriptions for tricyclics were defined as exposed. *Corrected for smoking status, diagnosis of depression, alcohol use and BMI. NSAID use corrected for in colorectal cancer only.