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. 2010 Dec 7;104(1):128–137. doi: 10.1038/sj.bjc.6606013

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Copyright © 2011 Cancer Research UK

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Leptin induces the phosphorylation of mTOR, 4E-BP1 and p70S6K1 in 4T1 cells. Representative western blot results for leptin-induced activation of mTOR and its downstream targets (4E-BP1 and S6K1) after treatment of 4T1 with kinase inhibitors: (A) rapamycin, (R for mTOR); (B) wortmannin (W, for PI-3K/AKT1) and (C) PD98059 (PD for MAPK). 4T1 cells were treated with leptin (0 or 1.2 nM) and inhibitors for 24 h.