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. 2010 Nov 30;104(1):110–119. doi: 10.1038/sj.bjc.6605992

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Copyright © 2011 Cancer Research UK

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Six selected cases (1–6) showing immunohistochemical expression of ANXA6 (A), HSP27 (B), PRDX2 (C), NCF2 (D), and TPM4 (E), magnification: × 400 (D1, D2, E2, C6 have magnification × 200), noncropped images with inserts. Observed expression of ANXA6 was membranous in SCE (A1), cytoplasmic and sporadic in CIN2/3, MicSCC and InvSCC (A2–A6). Expression of HSP27 in the nuclei was observed in CIN2/3, MicSCC (B2–B4), and less in InvSCC (B5–B6). Expression of PRDX2 was cytoplasmic in positive cases. Expression of NCF2 was observed in the cytoplasm (D2–D6), and expression of TPM4 in the cytoplasm was observed mainly in SCE (D1). Histopathological description. SCE (1): stratified layers of epithelial cells with a thin layer of parabasal cells. CIN2/3 (2–3): dysplastic cells with hyperchromatic irregular nuclei and koilocytar atypia with perinuclear clear vacuolisation as characteristic of HPV infection (marked with black arrows – C2, A4, B4) that gradually substitute epithelial layers from basal membrane throughout the epithelium forming carcinoma in situ. MisSCC (4): invasion of dysplastic cells into underlying stroma for <3 mm in depth and <7 mm horizontally. InvSCC (5–6): irregular infiltrates of tumor cells in connective tissue with inflammatory reaction.