Table 1. Serum angiogenic and inflammatory factors according to clinicopathological features in colorectal cancer patients.

		CRP (μg ml–1)			VEGF-A (pg ml–1)			Ang-2 (pg ml–1)
	Total N	Mean	Standard deviation	P-value	Mean	Standard deviation	P-value	Mean	Standard deviation	P-value
Gender (N total=344)
Female	171	5.44	3.05	<0.001a	432	375	0.084a	3050	1501	0.001a
Male	173	4.02	3.07		364	345		2536	1311
Age groups (N total=344)
31–50	13	3.52	2.42		275	210		2591	2413
51–60	28	4.53	3.14	0.030b	430	417	0.732b	2061	854	0.004b
61–70	102	4.12	3.05	0.026c	398	370	0.425c	2600	1306	0.022c
71–80	146	4.99	3.12		409	343		2928	1482
81–91	55	5.55	3.28		379	394		3206	1287
AJCC (N total=343)
I	69	3.20	2.57		367	332		2637	1501
IIA	115	5.00	3.14		323	263		2674	1301
IIB	29	5.50	3.48	<0.001b	495	450	0.021b	2972	1189	0.258b
IIIA	9	4.45	3.42	<0.001c	309	181	0.066c	2649	1344	0.093c
IIIB	71	4.85	3.07		441	430		2766	1357
IIIC	36	5.05	3.16		537	402		3331	1970
IV	14	7.38	2.08		459	469		3057	1207
T stage (N total=342)
T1	28	3.18	2.67		246	267		2369	1064
T2	59	3.71	2.77	<0.001b	440	359	0.064b	2776	1583	0.007b
T3	182	4.92	3.08	<0.001c	388	362	0.025c	2664	1278	0.007c
T4	73	5.64	3.38		447	383		3276	1672
N stage (N total=337)
N0	214	4.54	3.17		361	320		2709	1357
N1	79	4.86	3.01	0.181b	432	439	0.061b	2789	1325	0.069b
N2	44	5.48	3.14	0.07c	488	387	0.034c	3267	1872	0.021c
Grade (N total=245)
1	8	2.69	1.89	0.001b	566	412	0.094b	2552	865	0.087b
2	176	4.46	3.03	0.004c	376	358	0.335c	2719	1412	0.245c
3	58	5.91	3.33		467	403		3194	1716
Lymph/vascular invasion (N total=337)
No	236	4.49	3.01	0.102a	354	301	0.016a	2685	1268	<0.001a
Yes	101	5.14	3.42		469	431		3053	1754
Perineural invasion (N total=159)
No	135	4.50	3.29	0.331a	461	366	0.487a	2877	1522	0.805a
Yes	17	5.32	3.14		396	330		2977	1869
Necrosis (N total=180)
No	142	4.34	3.01	0.002a	357	354	0.559a	2536	1101	0.012a
Yes	38	6.12	3.35		395	351		3084	1463
Lymphocytic infiltrate (N total=267)
No	92	4.69	3.45		428	343		2738	1365
1	112	5.02	2.99	0.270b	360	321	0.192b	2728	1340	0.589b
2	49	4.21	3.02	0.153c	327	263	0.126c	2610	1411	0.176c
3	14	3.64	2.49		296	300		2246	701

Abbreviations: AJCC=American Joint Committee on Cancer; Ang-2=angiopoietin-2; ANOVA=analysis of variance; CRP=C-reactive protein; VEGF-A=vascular endothelial growth factor-A.

^aIndependent-samples t-test.

^bOne-way ANOVA.

^cTest for linear trend.