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. 2011 Feb 14;208(2):395–407. doi: 10.1084/jem.20100466

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© 2011 Okazaki et al.

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Figure 7. — Augmented Th1-response in BALB/c-Pdcd1^−/−Lag3^aida/aida mice. (A and B) The absolute number (A) and frequency (B) of each cell fraction in spleen of mice of indicated genotypes at 3–6 wk of age. (C and D) Frequencies of activated (CD62L⁻CD44⁺) and naive (CD62L⁺CD44⁻) CD4⁺ and CD8⁺ T cells in spleen of mice of indicated genotypes. (E) Frequencies of indicated cell fraction in CD45⁺ heart infiltrates from BALB/c-Pdcd1^−/−Lag3^−/− mice are shown. (F and G) Frequencies of CD4⁺ and CD8⁺ T cells that produced IFN-γ, IL-4, and IL-17 upon ex vivo stimulation. Splenocytes of BALB/c-Pdcd1^+/−Lag3^+/− and BALB/c-Pdcd1^−/−Lag3^−/− mice and heart infiltrates of BALB/c-Pdcd1^−/−Lag3^−/− mice were analyzed. Representative flow cytometric profiles are shown in G. (H) Quantities of mRNA encoding indicated genes in inflamed hearts of BALB/c-Pdcd1^−/−Lag3^aida/aida mice relative to that in spleens of BALB/c wild-type mice. Data are mean ± SEM (A–F) or mean + SEM (H). N.D., not detected. **, P < 0.01; *, P < 0.05. At least three mice of each genotype were analyzed in each experiment. Data of three BALB/c-Pdcd1^−/−Lag3^aida/aida and seven BALB/c-Pdcd1^−/−Lag3^−/− mice are combined in A–C.