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. 2011 Feb 14;208(2):227–234. doi: 10.1084/jem.20101459

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© 2011 Bigley et al.

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Figure 1. — Deficiency of peripheral blood DCs, monocytes, and lymphoid cells. Flow cytometry of PBMCs and proportion of lymphoid, monocyte, and DC fractions in the subjects relative to controls. Plots show equivalent numbers of total cells analyzed (75,000 for DCs; 65,000 for lymphocytes). Error bars indicate mean ± SD from a population of normal individuals (n = 11 for lymphoid cells; n = 28 for HLA-DR⁺ lineage⁻ cells). One of at least two independent results is shown for subjects 1–4. (A) CD3⁺ T cells, CD19⁺ B cells, and CD56⁺ NK cells. (B) HLA-DR⁺ lineage⁻ (CD3/19/56) cells further divided into CD14⁺ and CD16⁺ monocyte fractions and double-negative CD14⁻CD16⁻ cells, which comprise CD34⁺ progenitor cells, CD123⁺ PDCs, and CD11c⁺ myeloid DC fractions. (C) Quantitative analysis of monocyte/DC fractions, expressed as percentage of mononuclear cells, and lymphoid cells, expressed as percentage of cells in the lymphoid SSC/FSC gate, compared with healthy controls.