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. 2011 Feb 14;208(2):227–234. doi: 10.1084/jem.20101459

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© 2011 Bigley et al.

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Figure 5. — Elevation of Flt3L with T reg cell deficiency. (A) Serum Flt3L, M-CSF, and SCF concentrations measured by ELISA. Each subject was analyzed once. (B) Expression of Flt-3/CD135 and SCF-R/CD117 on BM CD34⁺ cells of subjects 1 and 3 compared with healthy controls and isotype (filled histogram). Each subject was analyzed twice. (C) Representative example of T reg cell analysis from subject versus normal control. Number indicates absolute count ×10⁶ /ml. (D) Absolute number of CD4⁺CD25^hiFoxP3⁺ T reg cells compared with HLA-DR⁺ lineage⁻ (CD3, 19, 20, 56) cells in subjects 1–4, as indicated, and controls (n = 21). Each subject was analyzed once. (E) Proportion of CD56⁺ and CD25⁺ CD3⁺ T cells in subjects 1–4 as indicated relative to controls.