Table 1. IRF6 Single SNP Association Analysis Results.
| SNP | Sample Set | Subset | PDT | Geno-PDT | APL |
|---|---|---|---|---|---|
| rs2235371 | NHW | All families | 0.001 | 0.0004 | 0.00007 |
| Positive FH | 0.23 | 0.28 | 0.12 | ||
| Negative FH | 0.0006 | 0.0006 | 0.0002 | ||
| Hispanic | All Families | 0.04 | 0.04 | 0.04 | |
| Positive FH | 0.56 | 0.81 | 0.77 | ||
| Negative FH | 0.05 | 0.05 | 0.03 | ||
| rs642961 | NHW | All families | 0.78 | 0.91 | 0.48 |
| Positive FH | 0.31 | 0.59 | 0.49 | ||
| Negative FH | 0.58 | 0.72 | 0.19 | ||
| Hispanic | All families | 0.05 | 0.11 | 0.01 | |
| Positive FH | 0.03 | 0.11 | --* | ||
| Negative FH | 0.41 | 0.59 | 0.08 |
*
variance too small to calculate p-value, PDT=Pedigree Disequilibrium Test, Geno-PDT=Genotypic Pedigree Disequilibrium Test, APL= Association in the Presence of Linkage, FH= family history, NHW = nonHispanic white