Fig. 8.
Total (over microfluidic chamber) fold change in marker expression over time for flow cases with average shear stresses of 2.8 and 15.6 dyn cm−2. Marker expression in flow cases (region by region) was divided by that of static controls and then averaged over all replicates and regions. The connecting lines represent a significant difference in marker expression between days for a given shear stress; † represents a significant difference in marker expression between shear stresses for a given day; and * represents a significant difference in expression between flow cases and static controls. Differences were statistically significant when p<0.05. A negative fold change represents a downregulation in marker expression while a positive change signals an upregulation. Error bars are 1 s.e.m. and n between 27 and 36 based on 9 regions for three or four sets of replicates