Table 1.

Functional distinctions between TGN Golgins and Tethering factors

Cargo	Golgin245 (p230)	Golgin97	GCC185	GCC88	TMF	GARP complex
Endogenous MPRs (not hybrid proteins with MPR cytoplasmic domains)		Not needed (Reddy et al. 2006)	Essential (Reddy et al. 2006; Derby et al. 2007) Binds Rab9, Rab6 and STX16, needed for this step (Ganley et al. 2008)			Essential (Pérez-Victoria 2008) Binds STX10, needed for this step (Liewen et al. 2005)
Shiga Toxin B	Essential (Yoshino et al. 2005)	Essential (Lu et al. 2004) MBoC 15, 4426		Not needed (Lieu et al. 2007) MBoC		Essential (Pérez-Victoria et al. 2008, 2009) Binds STX6, needed for this step
TGN38/46			Not needed (Derby 2007)	Essential for Syntaxin 6 localization (Lieu et al. 2007), MBoC (Lieu and Gleeson 2010)	(Fridmann-Sirkis et al. 2004)	Essential (Pérez-Victoria et al. 2008)