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Changes in plasma levels of cytokines and angiogenic factors during treatment (log2 transformed data). VCP, vandetanib, carboplatin, and paclitaxel; CP, carboplatin and paclitaxel; V, vandetanib; sVEGFR-2, soluble vascular endothelial growth factor receptor 2; B, baseline; IL-12, interleukin-12; MMP-9, matrix metalloproteinase-9; VEGF, vascular endothelial growth factor; interleukin-1 receptor antagonist; MCP-1, macrophage chemoattractant protein 1.
