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. Author manuscript; available in PMC: 2011 Oct 1.
Published in final edited form as: Acta Oncol. 2010 Oct;49(7):991–996. doi: 10.3109/0284186X.2010.500302

Figure 1. Schematic of workflow for dose painting with clinical treatment planning systems.

Figure 1

From a fused PET/CT image, PET uptake within the target volume is transformed to a voxel-based prescription via a linear redistribution of dose (prescription function). The prescription is discretized into equi-spaced dose levels (e.g. 5 levels), which form the basis for target substructures (dose discretization). Each substructure is prescribed the mean dose representative of the underlying voxel doses, with a DVH objective given by the fractional volume receiving this mean dose or higher. A clinically deliverable treatment plan is generated from IMRT optimization to substructure objectives, yielding a planned dose that can be compared back to the prescribed dose at every voxel.