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. Author manuscript; available in PMC: 2011 Feb 16.
Published in final edited form as: Med Sci Sports Exerc. 2008 Feb;40(2):223–233. doi: 10.1249/mss.0b013e31815bbba9

FIGURE 1.

FIGURE 1

Testosterone metabolism. Type 2 5α-reductase is found predominantly in the prostate and other genital tissues and is believed to be more important in conversion of testosterone to DHT, whereas type 1 is found throughout the body, including the skin, liver, and prostate (49). 3α-Diol-G is a metabolite of DHT. Type 3 3α-hydroxysteroid dehydrogenase (3α-HSD-3) converts DHT to 3α-androstanediol (3α-Diol), the immediate precursor of 3α-Diol-G, and is found in abdominal adipose tissue (46). 3α-Diol is converted to 3α-Diol-G by the glucuro(39)nosyltransferase UGT2B15, an enzyme also present in fat tissue (57).

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