Table 2.
D1, D2, and D3 enzymatic activities in brain (cerebrum) and liver tissues
| Genotype | Cerebrum D2 (fmol/h·mg protein) | Cerebrum D3 (fmol/h·mg protein) | Liver D1 (pmol/h·mg protein) |
|---|---|---|---|
| Wt | 31.8 ± 3.4 | 3685 ± 139 | 59.2 ± 2.4 |
| M8KO | 392.4 ± 8.2a | 2257 ± 403a | 99.9 ± 2.6a |
| D1KO | 31.2 ± 3.0 | 2970 ± 209b | NA |
| M8D1KO | 227.0 ± 12.5a | 2733 ± 104c | NA |
| D2KO | NA | 2927 ± 56b | 55.9 ± 2.9 |
| M8D2KO | NA | 2815 ± 466b | 99.8 ± 7.0a |
| D1D2KO | NA | 2797 ± 134c | NA |
| M8D1D2KO | NA | 2584 ± 110c | NA |
Data are expressed as mean ± se for five to seven mice in each group. NA, Not applicable.
a
P < 0.001, significant differences in comparison with the Wt.
b
P < 0.05, significant differences in comparison with the Wt.
c
P < 0.01, significant differences in comparison with the Wt.