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Plasma biomarkers. (A) Log10 levels of vascular endothelial growth factor (VEGF), interleukin-8 (IL-8), and basic fibroblast growth factor (bFGF) were evaluated before treatment and on day 15 and day 29. Each bar is based on 27 patient samples. (B) Circles indicate percent changes in average VEGF levels on day 29 from baseline. The red curve shows estimated probability of progression after two cycles, along with 90% confidence bounds (dotted curves) from logistic regression analysis.
