Table 4.

Estimated effects of types and disaggregated numbers of family childhood adversities (FCAs) on the first onset of four classes of DSM-IV/CIDI disorders^a

	Mood		Anxiety		Substance use		Impulse-control
	OR	(95% CI)	OR	(95% CI)	OR	(95% CI)	OR	(95% CI)
I. Types of FCAs
Parent mental disorders	3.36*	(1.69–6.77)	4.36*	(2.20–8.64)	4.05*	(1.96–8.38)	19.98*	(5.76–69.32)
Parental maladjustment	5.74	(0.61–54.02)	0.62	(0.16–2.36)	6.78*	(1.17–39.13)	7.25*	(1.90–27.70)
Childhood maltreatment	4.41*	(2.15–9.05)	3.10*	(1.11–8.64)	2.57*	(1.19–5.58)	2.54	(0.70–9.27)
Parental death	1.80	(0.92–3.50)	1.45	(0.62–3.36)	0.38*	(0.16–0.87)	1.47	(0.28–7.87)
Parental loss other than death	1.34	(0.58–3.08)	1.74	(0.66–4.59)	2.11*	(1.19–3.73)	1.92	(0.75–4.91)
Serious physical illness	1.62	(0.48–5.42)	0.88	(0.24–3.17)	0.23*	(0.07–0.77)	1.96	(0.61–6.23)
${\chi }_{(6)}^2$	24.02*		38.40*		33.40*		102.03*
II. Number of  family-dysfunction FCAs
0–1	1.0	–	1.0	–	1.0	–	1.0	–
2	0.17	(0.02–1.63)	0.12*	(0.02–0.71)	0.27*	(0.05–1.16)	0.10*	(0.02–0.65)
3	0.04	(<0.01–1.20)	1.43	(0.11–18.57)	0.13	(0.01–1.42)	0.03	(0.00–1.08)
${\chi }_{(2)}^2$	3.45		10.20*		3.46		5.89
III. Number of other FCAs
0–1	1.0	–	1.0	–	1.0	–	1.0	–
2	0.09*	0.01–0.98	0.13*	(0.02–0.73)	1.86	(0.62–5.63)	<0.01*	(<0.01–<0.01)
${\chi }_{(1)}^2$	3.92		5.34*		1.22		625.51*
PARP, % (95% CI)	41.5	(23.1–59.9)	34.5	(18.0–51.0)	37.2	(15.1–59.4)	57.2	(32.3–82.1)

OR, Odds ratio; CI, confidence interval; PARP, Population Attributable Risk Proportion.

^aSee footnotes a and e of Table 2 for a description of the dataset and overall modeling approach. The model used here was estimated with predictors for both types of FCAs and number of adversities (distinguishing number of family-dysfunction FCAs from number of non-family-dysfunction FCAs) in addition to the controls used in the models described in Table 2.

^*Significant at the p <0.05 level, two-sided test.