Table 5.
Functional annotation clusters for up- and down-regulated transcripts from CERTL obtained through DAVID webtool
| Database | Functional annotation | number of genes | p Value |
|---|---|---|---|
| up-regulated transcripts | |||
| GOTERM_CC_FAT | extracellular region | 22 | <0.0001 |
| SP_PIR_KEYWORDS | signal | 22 | <0.0001 |
| UP_SEQ_FEATURE | signal peptide | 22 | <0.0001 |
| GOTERM_BP_FAT | defense response | 9 | <0.0001 |
| GOTERM_BP_FAT | positive regulation of immune response | 7 | <0.0001 |
| GOTERM_BP_FAT | inflammatory response | 7 | <0.0001 |
| GOTERM_BP_FAT | immune effector process | 6 | <0.0001 |
| GOTERM_BP_FAT | complement activation | 5 | <0.0001 |
| GOTERM_BP_FAT | immunoglobulin mediated immune response | 5 | <0.0001 |
| GOTERM_BP_FAT | lymphocyte mediated immunity | 5 | <0.0001 |
| GOTERM_BP_FAT | activation of immune response | 5 | <0.0001 |
| KEGG_PATHWAY | Complement and coagulation cascades | 5 | <0.0001 |
| SP_PIR_KEYWORDS | complement pathway | 4 | <0.0001 |
| GOTERM_BP_FAT | response to steroid hormone stimulus | 4 | 0.0068 |
| GOTERM_BP_FAT | cell cycle | 7 | 0.0038 |
| down-regulated transcripts | |||
| GOTERM_BP_FAT | response to steroid hormone stimulus | 4 | 0.0068 |
| SP_PIR_KEYWORDS | cell cycle | 6 | 0.00045 |
| KEGG_PATHWAY | cell cycle | 4 | 0.0038 |
| GOTERM_BP_FAT | cell division | 5 | 0.0028 |
| GOTERM_BP_FAT | cell cycle | 7 | 0.0038 |
| GOTERM_BP_FAT | regulation of cell cycle | 6 | 0.00047 |
| SP_PIR_KEYWORDS | developmental protein | 6 | 0.0041 |
| UP_SEQ_FEATURE | metal ion-binding site:Zinc 1 | 3 | 0.0053 |
Enriched functional annotations found in GATHER (Table 4) and DAVID (table 5) appear in bolded style.