Table 3. Laboratory features at enrollment visit associated with survival in SCA patients.
Clinical features | Survived(n = 1,430; 94.3%) | Died(n = 86; 5.7%) | Odds Ratio(95% CI) | p | ||
n | n (%) or mean (SD) | n | n (%) or mean (SD) | |||
Age at enrollment (years) | 1,430 | 9.5 (7.8) | 86 | 10.2 (8.6) | 1.01 (0.98–1.04) | 0.408 |
White blood cell count (x109/L) | 1,307 | 15.9 (6.9) | 78 | 15.7 (7.3) | 0.99 (0.96–1.03) | 0.849 |
Hemoglobin (g/dL) | 1,306 | 7.6 (1.3) | 79 | 6.9 (1.6) | 0.73 (0.62–0.86) | <0.001 |
Mean Corpuscular volume (fL) | 1,298 | 79.2 (9.5) | 77 | 79.5 (10.9) | 1.00 (0.98–1.03) | 0.752 |
Reticulocyte (% of RBC) | 832 | 12.6 (7.1) | 33 | 13.1 (8.6) | 1.01 (0.96–1.06) | 0.670 |
Hemoglobin F (%) | 1,297 | 6.3 (4.7) | 63 | 6.6 (4.9) | 1.02 (0.96–1.07) | 0.575 |
Total Bilirubin (µmol/L) | 1,263 | 69.7 (56.7) | 79 | 87.5 (81.4) | 1.00 (1.00–1.01) | 0.010 |
Direct Bilirubin (µmol/L) | 1,157 | 20.9 (34.2) | 72 | 33.1 (57.6) | 1.00 (1.00–1.01) | 0.019 |
Indirect Bilirubin (µmol/L) | 1,140 | 51.5 (53.6) | 71 | 57.1 (60.4) | 1.01 (0.99–1.01) | 0.396 |
Lactate dehydrogenase (IU/L) | 559 | 965.4 (483.7) | 27 | 1,103.7 (339.3) | 1.00 (0.99–1.00) | 0.143 |
Aspartate transaminase (IU/L) | 1,307 | 50.1 (28.4) | 81 | 49.3 (24.1) | 0.99 (0.99–1.01) | 0.802 |
Alkaline phosphatase (IU/L) | 1,310 | 265.6 (124.2) | 81 | 276.7 (152.8) | 1.00 (0.99–1.00) | 0.442 |
Association between mortality and laboratory measurements at enrollment was explored using logistic regression.