Table 9. Octadecanoid oxylipins (nM) detected by UPLC (−)ESI-MS/MS in human plasma.
Parent Lipid | Classa | HMDB ID | Common Abbreviaton | HM Replicate Plasma (n = 3) | Pennington Plasma (n = 70) |
C18:2n6 | Diol | HMDB04705 | 12,13-DiHOME | 7.69±0.59 | 5.82±3 |
C18:2n6 | Diol | HMDB04704 | 9,10-DiHOME | 60.5±3.8 | 29.7±11 |
C18:2n6 | Epox | HMDB04702 | 12(13)-EpOME | 4.88±0.34 | 7.21±8.8 |
C18:2n6 | Epox | HMDB04701 | 9(10)-EpOME | 2.17±0.23 | 5.47±7.4 |
C18:2n6 | R-OH | HMDB04667 | 13-HODE | 47.3±0.53 | 58.2±28 |
C18:2n6 | R-OH | HMDB10223 | 9-HODE | 11.7±0.23 | 11±6.1 |
C18:2n6 | R-OOH | HMDB03871 | 13-HpODE | ND | 6.01±5.5 |
C18:2n6 | R-OOH | HMDB06940 | 9-HpODE | ND | 5.14±3.8 |
C18:2n6 | Epox,R = O | HMDB13623 | 12(13)Ep-9-KODE | 3.02±0.27 | 3.96±2.4 |
C18:2n6 | R = O | HMDB04668 | 13-KODE | 4.82±0.68 | 1.7±1.2 |
C18:2n6 | R = O | HMDB04669 | 9-KODE | 2.41±0.29 | 5.3±2.7 |
C18:2n6 | Triol | HMDB04708 | 9,12,13-TriHOME | 0.827±0.21 | 4.11±2.2 |
C18:2n6 | Triol | HMDB04710 | 9,10,13-TriHOME | 0.513±0.083 | 1.16±0.64 |
C18:3n3 | Diol | HMDB10208 | 15,16-DiHODE | 14.5±1 | 5.93±2.4 |
C18:3n3 | Diol | HMDB10201 | 12,13-DiHODE | <0.2 | 0.219±0.12 |
C18:3n3 | Diol | HMDB10221 | 9,10-DiHODE | 2.36±0.15 | 0.114±0.085 |
C18:3n3 | Epox | HMDB10206 | 15(16)-EpODE | 3.27±0.23 | 2.77±2.1 |
C18:3n3 | Epox | HMDB10200 | 12(13)-EpODE | 0.416±0.08 | 0.468±0.67 |
C18:3n3 | Epox | HMDB10220 | 9(10)-EpODE | 2.08±0.075 | 1.65±2.3 |
C18:3n3 | R-OH | HMDB10203 | 13-HOTE | 1.9±0.21 | 1.11±0.74 |
C18:3n3 | R-OH | HMDB10224 | 9-HOTE | 1.98±0.12 | 1.19±0.91 |
Class: R-OH - hydroxy fatty acid; R = O - keto fatty acid; Diol - dihydroxy fatty acid; Triol - trihydroxy fatty acid; Epox - epoxy fatty acid; LT - leukotriene; PG - prostaglandin.