Figure 6. Different effects on Kip and INK proteins.

Mechanical ventilation for 24 h significantly increased p27 ^Kip1 (A) and p57 ^Kip2 (B) protein levels. In contrast, p16 ^INK4a protein (D) was decreased by ventilation while p15 ^INK4b (C) was unchanged. Inserts show immunoblots of lung tissue of 7-day old rats ventilated for 24 h and non-ventilated 8-day old rats (controls). Blots were reprobed with β-actin for equal loading and transfer. Medians with 25^th and 75^th quartiles are shown, bars are 5^th and 95^th percentiles; n = 3 rat pups per time group. *p<0.05 versus non-ventilated group.