Table 1.
Subtype, Stage, Silverberg Grade, and S100A1 Score for Tissue Microarrays in Ovarian Cancer*
| Median (Range) Age (y) |
Median (Range) Preoperative Serum CA-125 (U/mL) |
Stage | N | S100A1+ | Silverberg Grade | N | S100A1+ | S100A1+ Overall | |
|---|---|---|---|---|---|---|---|---|---|
| Serous | |||||||||
| High-grade (n = 200) | 60.0 (37.6–86.0) | 150 (0–23,000) | I | 49 | 34 (69) | 1 | 0 | 0 (0) | 132 (66.0) |
| II | 86 | 54 (63) | 2 | 56 | 28 (50) | ||||
| III | 65 | 44 (68) | 3 | 144 | 104 (72) | ||||
| Low-grade (n = 12) | 59.2 (33.5–81.6) | 65 (6–325) | I | 1 | 1 (100) | 1 | 12 | 3 (25) | 3 (25) |
| II | 7 | 2 (29) | 2 | 0 | 0 (0) | ||||
| III | 4 | 0 (0) | 3 | 0 | 0 (0) | ||||
| Endometrioid (n = 125) | 54.1 (29.4–88.1) | 130 (8–13,000) | I | 69 | 8 (12) | 1 | 82 | 8 (10) | 14 (11.2) |
| II | 50 | 5 (10) | 2 | 35 | 5 (14) | ||||
| III | 6 | 1 (17) | 3 | 8 | 1 (13) | ||||
| Clear cell (n = 132) | 55.0 (28.1–89.0) | 64 (4–7,750) | I | 68 | 19 (28) | 1 | 0† | N/A | 28 (21.2) |
| II | 56 | 7 (13) | 2 | 0† | N/A | ||||
| III | 8 | 2 (25) | 3 | 132 | 28 (21.2) | ||||
| Mucinous (n = 31) | 56.4 (25.4–76.7) | 45 (7–650) | I | 18 | 0 (0) | 1 | 11 | 0 (0) | 1 (3) |
| II | 12 | 0 (0) | 2 | 18 | 1 (6) | ||||
| III | 1 | 1 (100) | 3 | 2 | 0 (0) | ||||
| Total (n = 500) | 56.6 (25.4–89.0) | 98 (0–23,000) | I | 205 | 62 (30.2) | 1 | 105 | 11 (10.5) | 178 (35.6) |
| II | 211 | 68 (32.2) | 2 | 109 | 34 (31.2) | ||||
| III | 84 | 48 (57) | 3 | 286 | 133 (46.5) | ||||
*
Data are given as number (percentage) unless otherwise indicated.
†
All clear cell carcinomas are considered high-grade.