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. Author manuscript; available in PMC: 2012 Jul 1.
Published in final edited form as: Ageing Res Rev. 2010 Aug 20;10(3):330–335. doi: 10.1016/j.arr.2010.08.004

Figure 2. Aging decreases AID and E47 mRNA expression, E47 mRNA stability and increases TTP.

Figure 2

B cells (106 cells/ml) were cultured with anti-CD40/IL-4, for 1 day (E47) or 7 days (AID), or left unstimulated. At the end of these times, cells were harvested, mRNA extracted and qPCR performed. Thirty young and thirty elderly subjects were evaluated. White columns: young; black columns, elderly. The differences between young and elderly subjects were evaluated by two-tailed Student’s t test. p<0.05 (*), p<0.01 (**).