Table 2.

Polymerization inhibition kinetics for each PN-treated tau construct^a

Tau	IC50 (µM)	Max Inhibition (% of wild-type tau)
WT	1.922 ± 0.608*	90.3 ± 0.73
Y18	1.329 ± 0.459*	90.5 ± 1.95
Y29	0.283 ± 0.107	89.1 ± 1.17
Y197	0.913 ± 0.146*	56.6 ± 5.79**
Y394	0.475 ± 0.029	88.0 ± 0.47
5XY→F	0.512 ± 0.027	77.4 ± 1.35

^aIC₅₀ – concentration at 50% inhibition

^*p≤0.05 compared to PN-treated Y29, Y394 and 5XY→F constructs

^**p≤0.05 compared to all other constructs