Table 2.
Representative S-nitrosylated proteins and their cellular functions
| Protein name | Gene name | Pathway |
|---|---|---|
| Type-1 angiotensin II receptor | AGTR1 | Receptor signaling |
| Dynamin-1/2 | DYN1, DYN2 | |
| Insulin receptor | INSR | |
| NMDA receptor | NMDAR2A, NMDAR1 | |
| Beta-arrestin 2 | ARRB2 | |
| MAP kinase 8 | MAPK8 | Signal transduction |
| Protein-tyrosine phosphatases, PTP1B, SHP1 | PTP1B, PTP1C | |
| Dexamethasone-induced Ras-related protein 1 | DEXRAS1 | |
| GTPase HRas, NRas | HRAS, NRAS | |
| Sarcoplasmic/endoplasmic reticulum Ca2+ ATPase | ATP2A1 | Muscle contraction |
| Myosin-9 | MYH9 | |
| Ryanodine receptor 1/2 | RYR1, RYR2 | |
| Apoptosis regulator Bcl-2 | BCL2 | Apoptosis |
| Caspase-3, -9 | CASP3, CASP9 | |
| E3 ubiquitin-protein ligase XIAP | XIAP | |
| Arginase-1 | ARG1 | NO synthesis |
| Argininosuccinate synthase | ASS1 | |
| Nitric oxide synthase, endothelial | NOS3 | |
| Glutaredoxin-1 | GRX | Redox regulation |
| Thioredoxin-1 | TRX1 | |
| Stress-70 protein, mitochondrial | HSPA9 | Heat shock response |
| Heat shock protein HSP 90-alpha | HSP90AA1 | |
| Elongation factor 1-alpha | EF1A | Gene regulation |
| Histone deacetylase 2 | HDAC2 | |
| Hypoxia-inducible factor 1-alpha | HIF1A | |
| Inhibitor of nuclear factor kappa-B kinase | IKKB | |
| Calcium/calmodulin-dependent protein kinase type II | CAMK2A | |
| E3 ubiquitin-protein ligase Mdm2 | MDM2 | |
| Nuclear factor NF-kappa-B p105 subunit | NFKB1 | |
| Tumor necrosis factor receptor superfamily | TNFRSF10A | |
| Hemoglobin | HBA1; HBA2 | Circulation |
| Tissue-type plasminogen activator | PLAT | |
| Voltage-gated potassium channel | KCNA8, KCNA5 | Membrane channels |
| Cytochrome c oxidase subunit 2 | MT-CO2 | Respiratory chain |
| Protein disulfide-isomerase | PDI | Protein homeostasis |
| Ubiquitin-conjugating enzyme E2 L3 | UBE2L3 | |
| Cytosolic phospholipase A2 | PLA2G4A | Others |
| Glucokinase | GCK | |
| Iron-responsive element-binding protein 2 | IREB2 | |
| Matrix metalloproteinase-9 | MMP9 | |
| Microsomal glutathione S-transferase 1 | MGST1 | |
| Syntaxin-1A | STX1A | |
| Vesicle-fusing ATPase | NSF |