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] Comparison of the RosettaEPR knowledge-based potential to the bounded potential. T4-lysozyme was folded de novo in Rosetta guided by 25 experimental restraints. Restraint violations were scored according to either a bounded potential or the EPR knowledge-based potential. The RMSDCα distributions of the resulting models when folded with optimally weighted restraint energies are compared to folding without restraints.
